Compositions and methods for inhibiting cd279 interactions
AssigneeVirogin Biotech Canada Ltd
InventorsWilliam Jia, Xuexian Bu, I-Fang Lee
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Abstract
Methods and compositions for inhibiting and/or interfering with interactions between (1) programmed Death-1 protein (also known as CD279) and (2) programmed death-ligand 1 (PD-L1) and/or programmed death-ligand 2 (PD-L2) are disclosed. In addition, methods and compositions for increasing IL-2 levels in a cell, and methods and compositions for preventing, treating, or ameliorating the effects of cancer in a subject, are disclosed.
Claims10
1-17. (canceled)
An expression cassette, comprising control sequences operably linked to a sequence which encodes a peptide comprising one of SEQ ID NO:1-SEQ ID NO:36, linked to a fragment crystallizable (Fc) region of an antibody.
A recombinant viral vector comprising an expression cassette that expresses a peptide comprising one of SEQ ID NO:1-SEQ ID NO:36, linked to a fragment crystallizable (Fc) region of an antibody.
Dependencies are inferred from the claim text.