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US 2020/0399306 A1Published application
High shear solid phase synthesis
AssigneeYissum Research Development Company of the Hebrew University of Jerusalem
InventorsChaim GILON, Moshe BENTOLILA
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Abstract
The present disclosure relates to solid phase synthesis of organic molecules and particularly to highly efficient methods for synthesizing polymers, such as peptides, nucleotides or saccharides, employing solid phase synthesis.
Claims21
1-51. (canceled)
A method for performing at least one cycle of solid phase synthesis of an organic molecule, the method comprising the steps of:
- i. providing a reactor comprising a reaction chamber and a stirring apparatus, wherein the stirring apparatus comprises an impeller having at least two blades rotatable about an axis;
- ii. inserting beads of functionalized polymeric resin and at least one solvent into the reactor to provide a reaction mixture, wherein the reaction mixture is in contact with the rotatable blades;
- iii. inserting at least one reactant into the reaction chamber;
- iv. spinning the impeller for a period of time, at a rotational rate of at least 600 rounds per minute (rpm), while maintaining a shear rate of at least 3·103 sec−1;
- thereby performing at least one cycle of the solid phase synthesis of the organic molecule.
2 more elements
Dependencies are inferred from the claim text.