Deoxynucleic Guanidines (DNG)- Modified Oligonucleotides and Methods of Synthesizing Deoxynucleic Guanidine Strands
AssigneeNorthwestern University
InventorsChad A. Mirkin, Kacper Skakuj, Katherine E. Bujold
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Abstract
Disclosed herein are spherical nucleic acids (SNAs) comprising oligonucleotides comprising one or more modified oligonucleotides, and methods of use thereof. Also disclosed are methods of synthesizing modified oligonucleotides for use in therapeutics, including deoxynucleic guanidine (DNG)-modified oligonucleotides.
Claims29
A spherical nucleic acid (SNA) comprising a nanoparticle functionalized with an oligonucleotide comprising at least one deoxynucleic guanidine modification (DNG).
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A method for synthesizing a deoxynucleic guanidine oligonucleotide comprising admixing an aminonucleoside with a thiourea nucleoside in the presence of an electrophilic iodine reagent, a base, and a solvent to form a deoxynucleic guanidine oligonucleotide, wherein the base has a pKa of about 7 to about 11, lacks α-protons, or both.
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Dependencies are inferred from the claim text.