Heterobifunctional inhibitors of e-selectin and galectin-3
AssigneeGlycoMimetics, Inc.
InventorsJohn L. MAGNANI, John M. PETERSON, Arun K. SARKAR, Yusufbhai U. VOHRA, Hong-Woon YANG
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Abstract
Compounds, compositions, and methods for treatment and/or prevention of at least one disease, disorder, and/or condition by inhibiting binding of an E-selectin, galectin-3, or E-selectin and galectin-3 to ligands a disclosed. For example, heterobifunctional inhibitors of E-selectin and galectin-3 are described and pharmaceutical compositions comprising at least one such agent is described.
Claims58
At least one compound chosen from compounds comprising an E-selectin inhibitor-Linker-galectin-3 inhibitor, a prodrug thereof, and pharmaceutically acceptable salts of any of the foregoing.
Dependencies are inferred from the claim text.