Dioxinoquinoline compounds, preparation method and uses thereof

A compound of formula (I), or a pharmaceutically acceptable salt, an isomer, a hydrate, a solvate, or a prodrug thereof,

• in the formula (I),
• Q is CH;
• G is O;
• Z is CH;
• L is selected from the group consisting of
• wherein X is H or C1-C3 alkyl;
• Y is H or C1-C3 alkyl;
• n is 0 to 3, and when n is 0, L represents
• R1 is C1-C6 alkyl substituted with 1 to 3 substituents selected from the group consisting of C1-C3 acyl, halogen, trifluoromethyl, cyano, —CONH2, —NRaRb and 4- to 7-membered heteroalicyclic group, wherein the 4- to 7-membered heteroalicyclic group is a 4- to 7-membered heteroalicyclic group containing 1 to 2 atoms selected from the group consisting of N, O, and S as ring atoms, and the 4- to 7-membered heteroalicyclic group is substituted with 1 to 3 substituents selected from the group consisting of halogen, C1-C3 alkyl, hydroxyl, —NH2, and C1-C3 acyl,
• Ra and Rb are each independently —H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyl substituted with C1-C3 alkoxy, C1-C6 alkyl substituted with C1-C3 alkylthio, C1-C6 alkyl substituted with substituted amino or unsubstituted amino, wherein the substituted amino is substituted with mono- or di-C1-C3 alkyl;
• R2, R3, and R4 are each independently H, C1-C3 alkyl or halogen;
• R5 is —H, C1-C9 alkyl, C3-C7 cycloalkyl, C1-C6 alkyl substituted with C3-C7 cycloalkyl, aryl, C1-C6 alkyl substituted with aryl, heteroaryl, or C1-C6 alkyl substituted with heteroaryl;
• the aryl and heteroaryl are unsubstituted, or are substituted with 1 to 3 substituents selected from the group consisting of one or more of the following:
• hydroxyl, amino, cyano, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino substituted with mono- or di-C1-C3 alkyl, halogen, trifluoromethyl, and methylsulfonyl;
• and
• the above heteroaryl is a monocyclic or bicyclic group containing 1 to 3 heteroatoms selected from the group consisting of N, O, and S and containing 5 to 10 ring atoms.