Urea-substituted aromatic ring-linked dioxinoquinoline compounds, preparation method and uses thereof

A compound represented by formula (I), or a pharmaceutically acceptable salt, an isomer, a hydrate, a solvate, or a prodrug thereof,

• in the formula (I),
• X is O or NH;
• Y is CH;
• Z is CH;
• R1 is C1-C6 alkyl substituted with 1 to 3 substituents selected from the group consisting of C1-C3 acyl, halogen, trifluoromethyl, cyano, —CONH2, —NRaRb and 4- to 7-membered heteroalicyclic group, wherein the 4- to 7-membered heteroalicyclic group is a 4- to 7-membered heteroalicyclic group containing 1 to 2 atoms selected from the group consisting of N, O, and S as ring atoms, and the 4- to 7-membered heteroalicyclic group is substituted with 1 to 3 substituents selected from the group consisting of halogen, C1-C3 alkyl, hydroxyl, —NH2, and C1-C3 acyl,
• Ra and Rb are each independently H, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkyl substituted with C1-C3 alkoxy, C1-C6 alkyl substituted with C1-C3 alkylthio, or C1-C6 alkyl substituted with substituted amino or unsubstituted amino, wherein the substituted amino is substituted with mono- or di-C1-C3 alkyl;
• R2, R3, and R4 are each independently H or halogen;
• R5 is H, C1-C9 alkyl, C3-C8 cycloalkyl, C1-C6 alkyl substituted with C3-C8 cycloalkyl, unsubstituted aryl or heteroaryl, or an aryl or heteroaryl group substituted with 1 to 3 substituents —B, wherein the substituents —B are each independently hydroxyl, cyano, C1-C3 alkyl, C1-C3 alkoxy, C1-C3 alkylthio, amino substituted with mono- or di-C1-C3 alkyl, unsubstituted amino, halogen, trifluoromethyl, aryloxy or methylsulfonyl;
• and
• the heteroaryl group is a monocyclic or bicyclic group containing 5 to 10 ring atoms, which contains 1 to 3 atoms selected from the group consisting of N, O, and S in the ring.