Inhibitors of trpc6

A compound of formula (I)

• Wherein:
• A is CR7 or N;
• U is CH or N;
• V is CR8 or N;
• W is CR9 or N;
• X is CH, CC1-6alkyl, COC1-6alkyl, or N;
• Y is CH or N;
• Z is CH, COH, COC1-6alkyl or N;
• R1 is selected from the group consisting of H and halogen;
• R2 is selected from the group consisting of H, C1-6alkyl, —CN, —CF3, —OCF3, C3-6cycloalkyl, OC1-6alkyl, and OC3-6cycloalkyl;
• when Z is COH, R1 may join with the hydroxyl group attached to the Z ring atom to form a central furanyl ring;
• R3 is selected from the group consisting of
• H,
• C1-6alkyl optionally substituted with one to three groups independently selected from the group consisting of halogen, hydroxy or methoxy, and
• C3-6cycloalkyl;
• R4 is selected from the group consisting of H, C1-6alkyl optionally substituted with hydroxyl, C3-6cycloalkyl;
• R5 is H or C1-6alkyl;
• R3 and R5 can together form a bicyclic ring;
• R6 is selected from the group consisting of
• H,
• C1-6alkyl,
• —CN,
• —CF3,
• —OCF3,
• C3-6cycloalkyl, and
• OC1-6alkyl optionally substituted one to three halogen;
• R7 is selected from the group consisting of H, C1-6alkyl, and OC1-6alkyl optionally substituted with one to three halogen;
• R8 is selected from the group consisting of
• H,
• C1-6alkyl optionally substituted with C3-6cycloalkyl or one to three halogen,
• halogen,
• —CN,
• —CF3,
• —NH2,
• phenyl,
• C3-6cycloalkyl,
• OC3-6cycloalkyl,
• OC1-6alkyl optionally substituted with one to three halogen or C3-6cycloalkyl optionally substituted with one to three halogen;
• and
• 1-fluoromethyl-cyclopropylmethoxy;
• R9 is selected from the group consisting of
• H,
• C1-6alkyl optionally substituted with one to three halogen,
• halogen,
• —CN,
• —CF3,
• OH,
• C3-6cycloalkyl,
• OC1-6alkyl optionally substituted with C3-6cycloalkyl or one to three halogen, and
• OC3-6cycloalkyl;
• when V is CR8 and W is CR9, R8 and R9 can together form a 5- to 6-membered fused heterocyclic ring;
• or a pharmaceutically acceptable salt thereof.