Pyrazolopyrimidine sulfone inhibitors of jak kinases and uses thereof

A compound of Formula (I)

• One embodiment provides a compound of Formula (I):
• or a stereoisomer or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is:
• C1-6alkyl;
• cyano-C1-6alkyl;
• C1-6alkoxy-(CO)—;
• —(CHRa)m—NRbRc;
• or —(CHRa)n-het1;
• R2 is:
• C1-6alkyl;
• hydroxy-C1-6alkyl;
• halo-C1-6alkyl;
• C1-6alkoxy-C1-6alkyl;
• C3-6cycloalkyl;
• —(CHRa)p—NRbRc;
• het2;
• —(CHRa)q-het3;
• or phenyl which may be unsubstituted or substituted once or twice with Rd;
• R3 is:
• hydrogen;
• or C1-6alkyl;
• R4 is:
• hydrogen;
• or C1-6alkyl;
• R5 is:
• hydrogen;
• or C1-6alkyl;
• R6 is:
• hydrogen;
• C1-6alkyl;
• or R2 and R6 together with the atoms to which they are attached may form a six membered ring;
• m is from 2 to 3;
• n is from 0 to 2;
• p is from 0 to 2;
• each Ra is independently:
• hydrogen;
• or C1-6alkyl;
• each Rb is independently:
• hydrogen;
• or C1-6alkyl;
• each Rc is independently:
• hydrogen;
• or C1-6alkyl;
• het1 is:
• tetrahydrofuranyl;
• azetidinyl;
• or pyrrolidinyl, each of which may be unsubstituted or substituted once or twice with Re;
• het2 is:
• pyridinyl;
• pyrimidinyl;
• pyrazolyl;
• imidazolyl;
• or isoquinolinyl which may be partially saturated;
• each of which may be unsubstituted or substituted once or twice with Rf;
• het3 is:
• azetidinyl;
• pyrrolidinyl;
• oxetanyl;
• or piperidinyl;
• each of which may be unsubstituted or substituted once with Rg;
• each Rd is independently:
• C1-6alkyl;
• hydroxy;
• C1-6alkoxy-C1-6alkyl;
• —(CHRa)q—NRbRc;
• or phenyl;
• each Re is independently:
• C1-6alkyl;
• or oxo;
• each Rf is independently:
• C1-6alkyl;
• hydroxy-C1-6alkyl;
• oxo;
• —(CHRa)r—NRbRc;
• —(CHRa)s-het4;
• each Rg is independently:
• C1-6alkyl;
• or acetyl;
• q is from 1 to 2;
• r is from 2 to 3;
• s is from 2 to 3;
• and
• het4 is:
• azetidin-1-yl;
• 1-methyl-azetidin-3-yl;
• quinuclidinyl;
• 1-methyl-pyrrolidin-2-yl;
• or 4-methylpiperazin-1-yl.