Tetrazole-substituted pyrazolopyrimidine inhibitors of jak kinases and uses thereof

A compound of Formula (I)

• or a stereoismer or pharmaceutically acceptable salt thereof,
• wherein:
• R1 is:
• hydroxyl-C1-C6alkyl;
• —(CRa1Ra2)m-het1;
• —(CRa1Ra2)nNRbRc;
• or —(CRa1Ra2)m—C3-6 cycloalkyl wherein the C3-6cycloalkyl moiety is substituted once with Rd;
• R2 is:
• halo;
• halo C1-C6alkoxy;
• C1-C6alkylthio;
• —SF2;
• or C3-C6cycloalkyl;
• R3 is:
• hydrogen;
• or C1-C6alkyl;
• R4 is:
• hydrogen;
• or C1-C6alkyl;
• R5 is:
• hydrogen;
• or C1-C6alkyl;
• R6 is:
• hydrogen;
• or C1-C6alkyl;
• or R2 and R6 together with the atoms to which they are attached may form a six-membered ring containing two heteroatoms each independently selected from O, N and S;
• m is from 0 to 2;
• n is from 0 to 3;
• each Ra1 is independently:
• hydrogen;
• or C1-C6alkyl;
• each Ra2 is independently:
• hydrogen;
• halo;
• or C1-C6alkyl;
• Rb is:
• hydrogen;
• or C1-C6alkyl;
• Rc is:
• hydrogen;
• C1-C6alkyl;
• an amino protecting group;
• or azetidinyl which may be unsubstituted or substituted once with C1-C6alkyl;
• het1 is a heterocyclyl selected from:
• azetidinyl;
• pyrrolidinyl;
• piperazinyl;
• piperidinyl;
• morpholinyl;
• and oxetanyl;
• each of which may be unsubstituted or substituted once with Rd and once or twice with Rg;
• Rd is:
• —(CRa1Ra2)p-het2;
• —(CRa1Ra2)q—NReRf;
• or —(CRa1Ra2)p—C3-6cycloalkyl wherein the C3-6cycloalkyl moiety is substituted once with —NReRf;
• p is from 0 to 2;
• q is from 0 to 4;
• Re is:
• hydrogen;
• or C1-C6alkyl;
• Rf is:
• hydrogen;
• C1-C6alkyl;
• or —CH2C2N(CH3)2;
• each Rg is:
• C1-C6alkyl;
• or halo;
• and
• Het2 is a heterocycle selected from:
• tetrahydropyranyl;
• azetidinyl;
• and pyrrolidinyl;
• each of which may be unsubstituted or substituted once with C1-C6alkyl or —NReRf.