Single-chain polymer-based target receptors for use in electrochemical detection of target analytes
AssigneeUniversity of New Hampshire
InventorsEdward Song, William Rudolf Seitz, Jeffrey M. Halpern
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Abstract
The present disclosure provides new approaches in developing templated polymer-based chemical receptors. At least some embodiments of the invention use a stimuli-responsive polymer [e.g., poly-Nisopropylacrylamide (pNIPAM)] as a polymer backbone with the incorporation of functional monomers (for analyte recognition). In at least some embodiments of the invention, vinylferrocene may be used as a redox-active label for electrochemical transduction.
Claims30
An electrochemical sensor, comprising:
- a single-chain polymer attached to a surface, wherein the single-chain polymer is capable of selectively binding a target analyte, wherein the selective binding detectably alters the conformation of the single-chain polymer.
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A single-chain polymer for use in electrochemical sensing, comprising:
- a carboxylic acid monomer;
- a monomer comprising a derivative of pyridine with a vinyl group;
- an organometallic compound;
- and
- an N-isopropaylcrylamide (NIPAM) backbone.
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A method for electrochemical sensing, comprising:
- contacting a sample with an electrochemical sensor comprising a surface modified with a covalently attached single-chain polymer comprising an N-isopropaylcrylamide (NIPAM) backbone, wherein the single-chain polymer is capable of selectively binding a target analyte, wherein the selective binding detectably alters the conformation of the single-chain polymer;
- and
- monitoring attachment of the target analyte to the single-chain polymer.
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Dependencies are inferred from the claim text.