US 2020/0392289 A1 · Biodegradable Polymer and Use Thereof

Abstract

This invention is directed to a biodegradable polymer that can be degraded in vivo. The biodegradable polymer comprises a biodegradable polymer segment having at least a biodegradable bond and two or more cationic components, wherein each of said cationic components is covalently attached to the biodegradable polymer segment and the two cationic components/molecules are separated by at least one biodegradable bond in the backbone. The biodegradable polymer can be used for targeting desired ceils in vivo including T cells, NK (natural killer) ceils, cancer cells, or a combination thereof, delivering genes, DNA, oligodeoxynucleotide, oligonucleotide, RNA, mRNA, RNAi, siRNA, microRNA, protein, peptide, antibody, fragment of an antibody, small molecule drug including chemotherapy drugs, or other bioactive agents into cells, or being used as a vaccine or drug for treating a disease such as a cancer in a subject.

Claims40

Dependent claims

-26. (canceled)

A bioactive composition comprising a biodegradable polymer and at least one bioactive agent,

wherein said biodegradable polymer comprises two or more cationic components and at least one biodegradable bond formed by biomolecules, wherein said two or more cationic components are separated by at least one of said at least one biodegradable bond, wherein said biodegradable polymer comprises at least one side chain;
and wherein said two or more cationic components are attached to said biomolecules covalently,
at least one of said two or more cationic components comprises at least one end amine group selected from the group consisting of —N(CH2)NH2, —N(CH2)2NH2, —N(CH2)3NH2, —N(CH2)N+H3, —N(CH2)2N+H3,
—N(CH2)3N+H3 and a combination thereof,
said at least one biodegradable bond is in the backbone of said biodegradable polymer, in at least one side chain of said at least one side chain of said biodegradable polymer, or in both said backbone and at least one side chain of said biodegradable polymer,
said at least one biodegradable bond comprises a peptide bond, an ester bond, a reducible disulfide bond or a combination thereof, and
said biomolecules comprise an amino acid, a lysine (Lys), a modified Lys, a glutamic acid (Glu), a modified Glu, an aspartic acid (Asp), a modified Asp, an arginine (Arg), a modified Arg, a linear polyLys, a branched polyLys, a linear polyGlu, a branched polyGlu, a linear polyArg, a branched polyArg or a combination thereof.

4 more elements

Dependencies are inferred from the claim text.

Biodegradable Polymer and Use Thereof

Life of this patent

Biodegradable Polymer and Use Thereof

Life of this patent

Abstract

Claims40