Pdl2 compounds
AssigneeIO Biotech ApS
InventorMads Hald ANDERSEN
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Abstract
The present invention relates to a peptide compound of PDL2 selected from a peptide fragment, a functional homologue, and a functional analogue, as well as to a nucleic acid, such as DNA or RNA, encoding the peptide compound, a vector, such as a virus vector, and a host cell, such as mammalian cell, comprising the vector. The peptide compound, nucleic acid, vector and host cell of the present invention are in particular, useful for the treatment or prevention of a cancer characterized by expression of PDL2.
Claims21
1-15. (canceled)
An isolated immunogenic peptide fragment of a human programmed death ligand 2 (PDL2) protein of SEQ ID NO:
- 1, which fragment is up to 100 amino acids in length and wherein the peptide fragment comprises or consists of a consecutive sequence in a range from 8 to 100 amino acids of SEQ ID NO:
- 1;
- or a pharmaceutically acceptable salt thereof.
A vaccine composition comprising an isolated peptide fragment, or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable additive, such as a carrier, adjuvant and/or preservative, wherein said peptide fragment is an immunogenic peptide fragment of a human programmed death ligand 2 (PDL2) protein of SEQ ID NO:
- 1, which fragment is up to 100 amino acids in length and wherein the peptide fragment comprises or consists of a consecutive sequence in a range from 8 to 100 amino acids of SEQ ID NO:
- 1.
A method of treating or preventing cancer in a patient, the method comprising administering to the patient an effective amount of a peptide fragment of a human programmed death ligand 2 (PDL2) protein of SEQ ID NO:
- 1, which fragment is up to 100 amino acids in length and wherein the peptide fragment comprises or consists of a consecutive sequence in a range from 8 to 100 amino acids of SEQ ID NO:
- 1;
- or a pharmaceutically acceptable salt thereof;
- or a nucleic acid comprising said peptide fragment;
- or a vector comprising a nucleic acid encoding said peptide fragment.
Dependencies are inferred from the claim text.