Compounds and methods for treating tight junction permeability
Assignee9 Meters Biopharma, Inc.
InventorsJay P. MADAN, Balasingham RADHAKRISHNAN, Sandeep LAUMAS, Christopher PRIOR
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Abstract
The present invention provides Larazotide derivative compositions that resist protease degradation, and in various embodiments, do not demonstrate an inverse dose response, and/or can be delivered at higher doses without loss of potency or efficacy, thereby allowing improved therapy more desirable dosing schedules.
Claims40
A peptide promoting epithelial and/or endothelial tight junction integrity, the peptide comprising the amino acid sequence of SEQ ID NO:1, with one or two amino acid substitutions at the N-terminus, and optionally one or two amino acid substitutions of the C-terminus.
A peptide promoting epthelial and/or endothelial tight junction integrity, the peptide comprising the addition of one amino acid to the N-terminus of the peptide of SEQ ID NO:
- 1.
A peptide promoting epthelial and/or endothelial tight junction integrity, the peptide comprising an addition of amino acid(s) to the N- and/or C-terminus with respect to the peptide of SEQ ID NO:1.
A cyclic peptide promoting epithelial or endothelial tight junction integrity, the peptide comprising the amino acid sequence of SEQ ID NO:1, with one or two amino acid substitutions allowing for cyclization.
Dependencies are inferred from the claim text.