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US 2020/0392135 A1Published application
Organic compounds
AssigneeIntra-Cellular Therapies, Inc.
InventorsLawrence P. WENNOGLE, Peng LI
Life of this patent
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Abstract
The invention relates to particular substituted fluorinated heterocycle fused gamma-carbolines, their prodrugs, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D1/D2 receptor signaling systems, and/or the treatment of residual symptoms.
Claims24
A compound of formula I,
- wherein:
- Z is —(C═O)—, —CH(OH)—, or —CF(OH)—;
- R1 is CH3, CF3, CF2H, or CFH2;
- R2 and R3 are each independently H or F;
- R4 and R5 are each independently H or F;
- provided that R2, R3, R4, and R5 are not all H when R1 is CH3 and Z is —(C═O)— or —CH(OH)—;
- in free or salt form.
4 more elements
Dependencies are inferred from the claim text.