US 2020/0392134 A1Published application

Method for purifying 2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo-[3.2.1]-oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiol-[1r-(exo-exo)]trihydrochloride

AssigneeInstitute of Nuclear Energy Research Atomic Energy Council, Executive Yuan

InventorsSHOW-WEN LIU, CHENG-FANG HSU, WEI-HSI CHEN, YU CHANG

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Abstract

A method for purifying 2-[[2-[[[3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiol-[1R-(exo-exo)]-hydrochloride is revealed. After medium pressure liquid chromatography and subsequent acid treatment, 2-[[2-[[[3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiol-[1R-(exo-exo)]-hydrochloride with high purity is obtained. The method for purifying can solve the problem that the product purity is not up to the standard for radiopharmaceuticals.

Claims8

Dependent claims

A method for purifying 2-[[2-[[[3-(4-Chlorophenyl)-8-methyl-8-azabicyclo[3.2.1]-oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiol-[1R-(exo-exo)]trihydrochloride comprising the steps of:

taking a mixed solution of precursors of dopamine transporter imaging agents to perform column chromatography and get a product;
and
taking the product and hydrochloric acid to carry out a substitution reaction and get 2-[[2-[[[3-(4-chlorophenyl)-8-methyl-8-azabicyclo [3.2.1]-oct-2-yl]methyl](2-mercaptoethyl)amino]ethyl]amino]ethanethiol-[1R-(exo-exo)]trihydrochloride;
wherein the mixed solution of precursors of dopamine transporter imaging agents includes the product and a plurality of impurities.

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Dependencies are inferred from the claim text.