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US 2020/0390885 A1Published application
Methods for enhancing antigen-specific immune responses
AssigneeThe Johns Hopkins University
InventorsTzyy-Choou Wu, Chien-Fu Hung
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AssigneeThe Johns Hopkins University
InventorsTzyy-Choou Wu, Chien-Fu Hung
Estimating the term…
Described herein are methods comprising administering to a mammalian subject an effective amount of an annexin chimeric fusion protein, wherein the annexin chimeric fusion protein comprises at least one immunogenic antigen, thereby enhancing the antigen specific immune response relative to administration of the immunogenic antigen alone. Methods and kits for treating or preventing recurrence of hyper proliferating diseases, e.g., cancer, are described. A method may comprise priming a mammal by administering to the mammal an effective amount of a chemotherapeutic agent and boosting the mammal by administering to the mammal an effective amount of an annexin chimeric fusion.
A method of inducing or enhancing an antigen-specific immune response in a mammal, comprising administering to the mammal an effective amount of an annexin chimeric fusion protein, wherein the annexin chimeric fusion protein comprises at least one immunogenic antigen, thereby enhancing the antigen specific immune response relative to administration of the immogenic antigen alone.
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A method of inducing or enhancing an antigen-specific immune response in a mammal, comprising the steps of:
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A method for treating or preventing advanced stage cancer in a mammal comprising (a) priming the mammal by administering to the mammal an effective amount of a chemotherapeutic agent;
A kit comprising a priming composition and a boosting composition, the kit comprising;
Dependencies are inferred from the claim text.