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US 2020/0390884 A1Published application
Methods and Compositions for Modulating AKT3
AssigneeAugusta University Research Institute, Inc.
InventorsSamir N. KHLEIF, Mikayel MKRTICHYAN, Iryna LEBEDYEVA, Thomas ALBERS
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Abstract
Compounds and compositions for selectively modulating Akt3 are provided. Methods of using the compounds are also provided. Because Akt3 modulates the suppressive function of natural Tregs and the polarization of induced Tregs, the disclosed compounds are useful for modulating immune responses.
Claims17
A compound selected from the group consisting of
- or an enantiomer, polymorph, or pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.