Novel adjuvant for animal and human vaccines
AssigneeWisconsin Alumni Research Foundation
InventorsAdel M. Talaat, Shaswath Chandrasekar
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Abstract
Quil-A chitosan spherical nanostructure complexes as well as methods of making and using such complexes are disclosed herein. Also provided are Quil-A chitosan spherical nanostructures loaded with one or more RNA, DNA, or protein payload molecules as well as methods of making and using such loaded complexes.
Claims21
A composition comprising disaggregated spherical nanostructures comprising Quil-A and chitosan, wherein the Quil-A and chitosan are present at a ratio between 1:15 and 1:100.
A method of forming a composition comprising Quil-A chitosan spherical nanostructures, comprising the steps of:
- heating a first solution comprising Quil-A at about 55° C. for about 30 minutes;
- heating a second solution comprising chitosan at about 55° C. for about 30 minutes;
- mixing equal volumes of the first and second solution to form a combined solution;
- vortex mixing the combined solution for about 30 seconds to form a combined, vortexed solution;
- and
- incubating the combined vortexed solution whereby a composition comprising Quil-A chitosan spherical nanostructures is formed.
Dependencies are inferred from the claim text.