Human japanese encephalitis virus antibodies and methods of use therefor
AssigneeVanderbilt University
InventorJames E. Crowe, Jr.
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Abstract
The present disclosure is directed to antibodies binding to and neutralizing Japanese Encephalitis virus and methods for use thereof.
Claims78
A method of detecting a Japanese Encephalitis virus infection in a subject comprising:
- (a) contacting a sample from said subject with an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Tables 3 and 4, respectively;
- and
- (b) detecting Japanese Encephalitis virus in said sample by binding of said antibody or antibody fragment to a Japanese Encephalitis virus antigen in said sample.
A method of treating a subject infected with Japanese Encephalitis virus, or reducing the likelihood of infection of a subject at risk of contracting Japanese Encephalitis virus, comprising delivering to said subject an antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Tables 3 and 4, respectively.
A monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences from Tables 3 and 4, respectively.
A hybridoma or engineered cell encoding an antibody or antibody fragment wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences from Tables 3 and 4, respectively.
A vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences from Tables 3 and 4, respectively.
A method of determining the antigenic integrity of an antigen comprising:
- (a) contacting a sample comprising said antigen with a first antibody or antibody fragment having clone-paired heavy and light chain CDR sequences from Tables 3 and 4, respectively;
- and
- (b) determining antigenic integrity of said antigen by detectable binding of said antibody or antibody fragment to said antigen.
A neutralizing human monoclonal antibody that binds to Japanese Encephalitis virus (JEV) epitope E-DIII.
Dependencies are inferred from the claim text.