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US 2020/0390845 A1Published application
Pharmaceutical formulations of c1 esterase inhibitor
AssigneeCSL Behring GmbH
InventorsHubert METZNER, Ernst-Juergen KANZY
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Abstract
The present invention relates to pharmaceutical formulations comprising the C1 esterase inhibitor (C1-INH), exhibiting a higher stability for prolonged storage and a reduced formation of aggregates of said esterase inhibitor (C1-INH) upon storage for ameliorated use in treating or preventing disorders related to kinin formation.
Claims21
A pharmaceutical formulation comprising
- (a) C1-INH at a concentration of about 400 IU/mL to 2,000 IU/mL;
- and
- (b) histidine or a salt thereof at a concentration of about 5 mM to 150 mM,
- wherein the formulation does not comprise citrate or phosphate.
1 more element
(canceled)
Dependencies are inferred from the claim text.