Anionically Charged Chitosan
AssigneeKiOmed Pharma
InventorsMickaël Chausson, Pierre Douette, Sandrine Emilia Gautier, Philippe Vaesen, Houtaï Choumane, Guillermo Rocasalbas
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Abstract
The present invention relates to a carboxyalkyl chitosan having a zeta potential, measured at pH 7.5, that is less than or equal to −20 mV, compositions comprising same, a process for manufacturing same, and various applications thereof, in particular in the field of therapy, rheumatology, ophthalmology, esthetic medicine, plastic surgery, internal surgery, dermatology or cosmetics.
Claims21
1-16. (canceled)
A carboxyalkyl chitosan comprising glucosamine units, N-acetyl-glucosamine units, and glucosamine units substituted by a carboxyalkyl group, wherein the carboxyalkyl chitosan has:
- a zeta potential, measured at pH 7.5, that is lower than or equal to −18 mV;
- a degree of acetylation in a range of about 40% to about 80%, expressed at the number of moles of N-acetyl-glucosamine units relative to the number of moles of total units;
- and
- a degree of substitution by the carboxyalkyl group that is greater than 20% expressed as the number of moles of the substituent carboxyalkyl group relative to the number of moles of total units.
Dependencies are inferred from the claim text.