Glycan polymers and related methods thereof
AssigneeKaleido Biosciences, Inc.
InventorsMolly Krisann Gibson, Christopher Matthew Liu, Geoffrey A. von Maltzahn, Han Yuan
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Abstract
Compositions of glycan polymers and methods of making and manufacturing the same are described herein. Also provided are methods of treating a disease or disorder with a glycan polymer preparation.
Claims36
A method of treating a subject having a disease or disorder associated with an unwanted level of a metabolite wherein the metabolite is trimethylamine (TMA) or trimethylamine N-oxide (TMAO), comprising:
- selecting a glycan polymer preparation on the basis or knowledge that it modulates the production or level of the metabolite, and
- administering an amount of the glycan polymer preparation effective to result in a modulation of the level of the metabolite, thereby treating the disease or disorder,
- wherein the glycan polymer preparation comprises glucose and at least one alpha-glycosidic bond,
- wherein the alpha-glycosidic bond is an alpha-1,3 glycosidic bond, alpha-1,4 glycosidic bond, or a combination thereof, and
- wherein the mean degree of polymerization (DP) of the preparation is between DP3-15.
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Dependencies are inferred from the claim text.