Synergistic Enhancement of the Delivery of Nucleic Acids via Blended Formulations
AssigneeTranslate Bio, Inc.
InventorsFrank DeRosa, Lianne Smith, Michael Heartlein, Braydon Charles Guild
Life of this patent
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Abstract
Disclosed herein are pharmaceutical compositions that comprise “blends” of lipid nanoparticles and related methods of using such blended compositions to deliver polynucleotides to one or more target cells, tissues or organs. The blended compositions are generally characterized as being able to efficiently deliver polynucleotides to target cells and by their ability to enhance the expression of such polynucleotides and the production of functional proteins by target cells.
Claims28
A method of delivering a messenger RNA (mRNA) to a subject, comprising administering to the subject a pharmaceutical composition comprising an mRNA and a blend of at least a first lipid nanoparticle and a second lipid nanoparticle, wherein the first lipid nanoparticle comprises the mRNA;
- and wherein the first lipid nanoparticle comprises at least one lipid distinct from the second lipid nanoparticle.
(canceled)
(canceled)
9-16. (canceled)
18-23. (canceled)
26-32. (canceled)
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A pharmaceutical composition for delivery of messenger RNA (mRNA) polynucleotides to a cell, the composition comprising a blend of a first lipid nanoparticle and a second lipid nanoparticle, wherein the first lipid nanoparticle comprises the mRNA;
- and wherein the first lipid nanoparticle comprises at least one lipid distinct from the second lipid nanoparticle.
43-68. (canceled)
A method of delivering a messenger RNA (mRNA), comprising administering the mRNA formulated in at least two distinct lipid formulations.
71-82. (canceled)
Dependencies are inferred from the claim text.