Directed differentiation of oligodendrocyte precursor cells to a myelinating cell fate
AssigneesThe Scripps Research Institute, Novartis AG
InventorsPeter Schultz, Luke Lairson, Vishal Deshmukh, Costas Lyssiotis
Life of this patent
Estimating the term…
Abstract
The present invention provides methods of inducing differentiation of oligodendrocyte progenitor cells to a mature myelinating cell fate with a neurotransmitter receptor modulating agent. The present invention also provides methods of stimulating increased myelination in a subject in need thereof by administering said neurotransmitter receptor modulating agent. Methods of treating a subject having a demyelinating disease using a neurotransmitter receptor modulating agent are also provided.
Claims13
1-54. (canceled)
A method of treating a human subject having multiple sclerosis, the method comprising:
- (a) identifying a human subject diagnosed with multiple sclerosis and being treated with an immunomodulatory agent;
- and
- (b) administering to the human subject a muscarinic receptor antagonist.
Dependencies are inferred from the claim text.