Topical acyclovir formulations and uses thereof
AssigneePropella Therapeutics, Inc.
InventorMatthew J. Sharp
Life of this patent
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Abstract
Provided herein are gel formulations of acyclovir with a low concentration of acyclovir, which can be used, for example, for the treatment of recurrent herpes labialis (cold sores) in immunocompetent adults and adolescents 12 years of age and older. The gel formulation can be an aqueous gel formulation, an emulsified gel formulation, or a non-aqueous gel formulation.
Claims30
An aqueous gel formulation comprising acyclovir dissolved or partially suspended in an aqueous gel,
- wherein the acyclovir is in an amount of about 0.05% to about 0.5% by weight of the aqueous gel formulation,
- wherein the aqueous gel comprises a solvent system and an effective amount of a gel-forming agent,
- wherein the solvent system comprises water in an amount of about 20% to about 80% by weight of the aqueous gel formulation;
- and one or more water-miscible organic solvents in an amount of about 15% to about 70% by weight of the aqueous gel formulation;
- and
- wherein the aqueous gel formulation is formulated for topical use.
An emulsified gel formulation comprising acyclovir dissolved or partially suspended in an emulsified gel,
- wherein the acyclovir is in an amount of about 0.05% to about 0.5% by weight of the emulsified gel formulation,
- wherein the emulsified gel comprises a solvent system, an oil, an emulsifier and an effective amount of a gel-forming agent,
- wherein the solvent system comprises water in an amount of about 20% to about 80% by weight of the emulsified gel formulation;
- and one or more water-miscible organic solvents in an amount of about 15% to about 70% by weight of the emulsified gel formulation;
- and
- wherein the emulsified gel formulation is formulated for topical use.
A non-aqueous gel formulation comprising acyclovir dissolved or partially suspended in a non-aqueous gel,
- wherein the acyclovir is in an amount of about 0.05% to about 0.5% by weight of the non-aqueous gel formulation,
- wherein the non-aqueous gel comprises a solvent system and an effective amount of a gel-forming agent,
- wherein the solvent system comprises one or more solvents selected from propylene glycol, glycerol, diethylene glycol monoethyl ether, dimethyl sulfoxide, a low molecular weight polyethylene glycol, and combinations thereof;
- and
- wherein the non-aqueous gel formulation is formulated for topical use.
An aqueous gel formulation comprising:
- a) acyclovir in an amount of about 0.05% to about 0.5% by weight of the aqueous gel formulation;
- b) water;
- c) diethylene glycol monoethyl ether;
- and d) a gel-forming agent.
Dependencies are inferred from the claim text.