Treating cancer with atr inhibitors
AssigneeVertex Pharmaceuticals Incorporated
InventorsJohn Robert POLLARD, Philip Michael REAPER
Life of this patent
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Abstract
This invention relates to methods and compositions for treating pancreatic cancer. More specifically, this invention relates to treating pancreatic cancer with certain ATR inhibitors in combination with gemcitabine and/or radiation therapy. This invention also relates to methods and compositions for treating non-small cell lung cancer. More specifically, this invention relates to treating non-small cell lung cancer with an ATR inhibitor in combination with cisplatin or carboplatin, etoposide, and ionizing radiation.
Claims10
1-22. (canceled)
A method for treatment of pancreatic cancer in a patient, comprising administering to the patient in need thereof an effective amount of a compound of formula 822:
- in combination with gemcitabine, radiation, or gemcitabine and radiation.
A method of killing hypoxic pancreatic cancer cells in a patient, comprising administering to a patient in need thereof an effective amount of a compound of formula 822:
- in combination with gemcitabine, radiation, or gemcitabine and radiation.
Dependencies are inferred from the claim text.