Methods of administering tolperisone

A method of treating a patient with muscle spasm or spastic syndrome comprising (1) assessing the patient's routine daily activities, (2) determining if one or more of said activities could be, or is/are being, compromised by administering a drug effective to treat muscle spasm or spastic syndrome, but also known to have a sedative effect and (3) substituting said drug with tolperisone or a pharmaceutically acceptable salt thereof, and administering tolperisone or a pharmaceutically acceptable salt thereof in an amount effective to treat muscle spasm or spastic syndrome without compromising the patient's routine daily activities.

A method of treating a patient with muscle spasm or spastic syndrome, comprising administering to the patient a therapeutically effective amount of tolperisone or a pharmaceutically acceptable salt thereof, and wherein the patient was previously treated with a muscle relaxant but treatment was discontinued because of the muscle relaxant's sedative effect.

A method of treating a patient with muscle spasm or spastic syndrome, comprising administering to the patient a therapeutically effective amount of tolperisone or a pharmaceutically acceptable salt thereof, and wherein an improvement is also seen in the patient's cognitive function.

A method of determining the suitability of a drug for treating a patient suffering from muscle spasm or spastic syndrome, comprising conducting a driving simulation study and comparing the sedative effect of the drug against a standard therapy for treating muscle spasm or the spastic syndrome.