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AssigneeCardero Therapeutics, Inc.
InventorsGeorge Frederic SCHREINER, Guillermo CEBALLOS, Sundeep DUGAR
Estimating the term…
The present invention relates to compounds and compositions and their applications as pharmaceuticals for treating, preventing, or reversing injury to skeletal or cardiac muscles, for treating or preventing diseases relating to the structure and function of skeletal or cardiac muscle, arid for inducing regeneration or restructuring of skeletal or cardiac muscle as a means of treating diseases relating to abnormalities in skeletal or cardiac muscle structure and function in a human or animal subject. Further aspects relate to the same or similar applications for bone and bone diseases.
1-18. (canceled)
A method of increasing expression of one or more proteins selected from the group consisting of the sarcoglycan family of proteins, dystrophin, dysferlin, and utrophin in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of (+)-epicatechin and/or (−)-epicatechin or an epicatechin derivative of either (+)-epicatechin or (−)-epicatechin, or a salt of any of the foregoing.
A method of treating a disease or condition associated with deficient expression of one or more proteins selected from the group consisting of the sarcoglycan family of proteins, dystrophin, dysferlin, and utrophin in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of (+)-epicatechin and/or (−)-epicatechin or an epicatechin derivative of either (+)-epicatechin or (−)-epicatechin, or a salt of any of the foregoing.
A method of improving deficient muscle function, preventing muscle weakening, or reversing a state of muscle weakness due to deficient expression of one or more proteins selected from the group consisting of the sarcoglycan family of proteins, dystrophin, dysferlin, and utrophin in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of (+)-epicatechin and/or (−)-epicatechin or an epicatechin derivative of either (+)-epicatechin or (−)-epicatechin, or a salt of any of the foregoing.
Dependencies are inferred from the claim text.