A method for the treatment or prevention of a disease of the posterior segment of the eye, comprising topically administering onto eye surface a therapeutically effective amount of dobesilic acid or an ester thereof, or a pharmaceutically acceptable salt of the dobesilic acid or dobesilic acid ester in a subject in need thereof, including a human, wherein the treatment comprises administration of a topical dose of the dobesilic acid or ester thereof, or the pharmaceutically acceptable salt of the dobesilic acid or dobesilic acid ester, from 0.01 mg/day to 400 mg/day.