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US 2020/0390718 A1Published application
Methods and compositions for attenuated anti-viral transfer vector immune response
AssigneeSelecta Biosciences, Inc.
InventorsTakashi Kei Kishimoto, Petr Ilyinskii
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Abstract
Provided herein are methods and related compositions or kits for administering viral transfer vectors in combination with synthetic nanocarriers comprising an immunosuppressant and a corticosteroid.
Claims24
A composition comprising:
- a viral transfer vector, synthetic nanocarriers comprising an immunosuppressant, and a corticosteroid that is not coupled to a nanocarrier.
4-37. (canceled)
(canceled)
A method comprising:
- establishing an anti-viral vector attenuated response in a subject by concomitant administration of synthetic nanocarriers comprising an immunosuppressant, a viral transfer transfer vector, and a corticosteroid that is not coupled to a nanocarrier to the subject.
A method comprising:
- escalating transgene expression of a viral transfer vector in a subject by repeatedly, concomitantly administering to the subject synthetic nanocarriers comprising an immunosuppressant, a viral transfer vector, and a corticosteroid that is not coupled to a nanocarrier to the subject.
54-55. (canceled)
(canceled)
Dependencies are inferred from the claim text.