Procedure for preparing enteric-coated pellets containing a proton pump inhibitor and multi-particle pharmaceutical compositions containing them

A pharmaceutical composition, comprising:

• enteric-coated pellets having an average diameter between 350 and 710 microns, the enteric-coated pellets comprising:
• pure cellulose cores, wherein the cores have a particle size range between 150 and 500 microns,
• a coating disposed on the pure cellulose cores, the coating containing each of:
• a proton pump inhibitor with benzimidazole structure in an amount greater than 10.5% by weight with respect to the total weight of the enteric-coated pellets, a dibasic amino acid selected from the group consisting of lysine, histidine and L-arginine, and polyvinylpyrrolidone, wherein the dibasic amino acid is present in an amount less than or equal to 10% by weight in relation to the weight of the proton pump inhibitor, and
• an enteric coating disposed over said coating,
• wherein enteric-coated pellets that contain pure cellulose cores having an average diameter between 150 and 300 microns have an average diameter between 350 and 590 microns and enteric-coated pellets that contain pure cellulose cores with an average diameter between 300 and 500 microns have an average diameter between 500 and 710 microns.