Dendrimers for sustained release of compounds
AssigneeWayne State University
InventorsKannan Rangaramanujam, Raymond Iezzi, Bharath Raja Guru, Sujatha Kannan
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Abstract
Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular degeneration, diabetic retinopathy, and retinitis pigmentosa.
Claims14
1-36. (canceled)
A method of treating microglia or macrophage-mediated inflammation comprising administering a composition comprising a polyamidoamine (PAMAM) with free hydroxyl terminal groups and one or more biologically active agents conjugated thereto, wherein the inflammation is caused by a disease of the retina, central nervous system, the spinal cord, and/or the peripheral nervous system.
Dependencies are inferred from the claim text.