System and Method for Calculating Cardiac Pulse Transit or Arrival Time Information

An electronic system for calculating a subject's cardiac pulse transit time or pulse arrival time information, using a primary cardiac pulse signal and an electronic audio signal, wherein the electronic audio signal comprises information representative of a human voice signal in a time-domain, the human voice signal comprising a vowel audio sound of a certain duration and a fundamental frequency (F0);

• and wherein the electronic system comprises:
• a signal receiving module configured to receive the electronic audio signal and the primary cardiac pulse signal, wherein the electronic audio signal and the primary cardiac pulse signal are synchronized time-domain signals;
• an audio processing module configured to generate a power spectral profile of a section of the electronic audio signal, and to detect the fundamental frequency (F0) of the generated power spectral profile;
• a denoising module configured to filter the received audio signal within a band around at least the detected fundamental frequency (F0) to thereby generate a denoised audio signal;
• a signal transformation module configured to generate a time-domain intermediate signal that captures one or more of:
• a frequency, an amplitude, or a phase of the denoised audio signal;
• a beat detection module configured to detect at least one intermediate signal fiducial point, within a human cardiac band, in the intermediate signal;
• a primary cardiac pulse beat detection module configured to detect at least one primary cardiac pulse fiducial point, within a human cardiac band, in the primary cardiac pulse signal;
• and
• a cardiac pulse transit/arrival time module configured to calculate pulse transit time or pulse arrival time information between the at least one detected primary cardiac pulse fiducial point and the at least one detected intermediate signal fiducial point.