Antimicrobial gallium compounds and methods
AssigneeBoard of Supervisors of Louisiana State University and Agricultural and Mechanical College
InventorXiaoming XU
Life of this patent
Estimating the term…
Abstract
This invention relates to antimicrobial gallium compounds, and to monomers containing gallium complex moieties that can be used in oral care products and dental materials, and which can reduce or eliminate dental caries and bacterial or fungal infections associated with medical and dental devices.
Claims27
1) An antimicrobial composition comprising a chemical compound having the following formulae:
- wherein, M is a positive ion of hydrogen, sodium, potassium, ammonium, or a quaternary ammonium;
- wherein L is a chelating ligand;
- wherein X is an anion including hydroxide, nitrate, chloride, and fluoride;
- wherein j is an integer from 0 to 4;
- wherein l is an integer number from 1 to 3;
- wherein m is an integer number from 0 to 6;
- wherein n is an integer number from 0 to 6;
- wherein k is an integer number from 1 to 3.
- wherein, R is a substituted or unsubstituted aliphatic or aromatic group having 2 to 50 carbon atoms;
- and having at least one polymerizable group;
- wherein, R′ is a substituted or unsubstituted aliphatic or aromatic group having 2 to 50 carbon atoms, and having at least one polymerizable group;
- and
- wherein, A is a substituted or unsubstituted aliphatic or aromatic linkage group having 1 to 100 carbon atoms.
15) A glass ionomer containing 0.1% to 20% of antimicrobial compound having formulas (1).
16) A resin-modified glass ionomer containing 0.1% to 20% of antimicrobial compound having formulas (1) or formulas (2) or both.
17) A tooth paste containing 0.1% to 5% of antimicrobial compound having formulas (1).
18) A topic agent containing 0.1% to 10% of antimicrobial compound having formulas (1).
20) A mouth rinse containing 0.01% to 5% of antimicrobial compound having formulas (1).
24) A method of preparing an antibacterial fluoride-releasing glass powders for glass ionomers and resin-modified glass ionomers containing a compound of Formulas (1), the method comprising the following steps:
- a) Mixing the following ingredients (wt %) in a ceramic or platinum crucible:
- SiO2, 29%, CaF2 34%, AlPO49.9%, Al2O3 5-11%, Ga2O3 5-11%, AlF3 0-5%, GaF3 0-5%, Na3AlF6 0-5%, Na3GaF6 0-5%, and SrO2 and or BaO2. 0.1%.
- b) Heating the above mixture in a furnace or oven until the mixture is completely melted.
- c) Quenching the molten glass by quickly pouring it into deionized water.
- d) Collecting the cooled glass, drying and grinding it into powder.
Dependencies are inferred from the claim text.