Genetically modified non-human animals with humanized immunoglobulin locus
AssigneeBeijing Biocytogen Co., Ltd
InventorsYuelei Shen, Jiawei Yao, Huizhen ZHAO, Yabo ZHANG, Lili Liu, Hui LU, Shuwen HUANG
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to genetically modified animals and cells with humanized heavy chain immunoglobulin locus and/or humanized light chain immunoglobulin locus.
Claims33
A genetically-modified, non-human animal comprising at an endogenous heavy chain immunoglobulin gene locus, one or more human IGHV genes, one or more human IGHD genes, and one or more human IGHJ genes, wherein the human IGHV genes, the human IGHD genes, and the human IGHJ genes are operably linked and can undergo VDJ rearrangement.
(canceled)
(canceled)
-9. (canceled)
(canceled)
(canceled)
(canceled)
(canceled)
-37. (canceled)
A genetically-modified, non-human animal comprising at an endogenous light chain immunoglobulin gene locus, one or more human IGKV genes and one or more human IGKJ genes.
(canceled)
-48. (canceled)
A genetically-modified, non-human animal whose genome comprises an endogenous heavy chain immunoglobulin locus comprising:
- a replacement of one or more endogenous IGHV, endogenous IGHD, and endogenous IGHJ genes with one or more human IGHV, human IGHD, and human IGHJ genes, wherein human IGHV, human IGHD, and human IGHJ genes are operably linked to one or more of endogenous IGHM, IGHδ, IGHG, IGHE, and IGHA genes.
-57. (canceled)
-71. (canceled)
-75. (canceled)
Dependencies are inferred from the claim text.