Methods of treatment of muscular dystrophies
OwnerKin-Hung (Peony) YU, Elias KOUCHAKJI +2inventors
InventorsKin-Hung (Peony) YU, Elias KOUCHAKJI, Bassem ELMANKABADI, Tro SEKAYAN
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Abstract
The invention relates to methods and agents useful for treating muscular dystrophies (MDs), in particular, Duchenne muscular dystrophy (DMD). Methods and agents for treating various physiological and pathological features associated with muscular dystrophies are also provided.
Claims21
A method of improving pulmonary function in a subject with a muscular dystrophy, the method comprising administering to a subject in need thereof an effective amount of an agent that inhibits connective tissue growth factor (CTGF), thereby improving the subject's pulmonary function.
A method of improving cardiac function in a subject with a muscular dystrophy, the method comprising administering to a subject in need thereof an effective amount of an agent that inhibits connective tissue growth factor (CTGF), thereby improving the subject's cardiac function.
A method of reducing the development of or reducing the progression rate of cardiac fibrosis in a subject with a muscular dystrophy, the method comprising administering to a subject in need thereof an effective amount of an anti-CTGF agent, thereby reducing the development of or reducing the progression rate of cardiac fibrosis in the subject.
A method of increasing the muscle strength of a subject with a muscular dystrophy, the method comprising administering to a subject in need thereof an effective amount of an anti-CTGF agent, thereby increasing the subject's muscle strength.
A method for reducing muscle inflammation, muscle edema, fat infiltration or percentage of dystrophic muscle composition in a subject with a muscular dystrophy, the method comprising administering to the subject an effective amount of an anti-CTGF agent, thereby reducing muscle inflammation, muscle edema, fat infiltration or percentage of dystrophic muscle composition in the subject.
Dependencies are inferred from the claim text.