Methods of inactivating viral contaminants
AssigneeIchnos Sciences SA
InventorsFilipa ABRANTES, Sonia LETESTU, Laure CAHUZAC, Lionel DUARTE
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Abstract
The present invention relates to a method for preparing an antibody-containing solution free viral contaminants starting from cultured cells are described. The method include a step of subjecting the antibody containing solution to a mix of solvent and detergent or to high pH.
Claims24
A method for preparing a virus-inactivated antibody solution, comprising the steps of (i) harvesting antibody material produced by transfected cells comprising the coding sequences of the antibody, which have undergone cell culture, and (ii) treating the harvested antibody material with a viral inactivation treatment, wherein the viral inactivation treatment comprises an incubation with a mixture of a solvent and a detergent or incubation at high pH.
A method of removal of impurities from a cell harvest material comprising treating the cell harvest with high pH followed by a filtration step.
Dependencies are inferred from the claim text.