Back to results
US 2020/0369743 A1Published application
Methods and compositions for chimeric antigen receptor targeting cancer cells
AssigneesThe University of North Carolina at Chapel Hill, The General Hospital Corporation
InventorsGianpietro Dotti, Soldano Ferrone, Hongwei Du, Xinhui Wang, Cristina Ferrone
Life of this patent
Estimating the term…
Abstract
The present invention provides a chimeric antigen receptor (CAR) that recognizes B7-H3 (CD276), as well as methods of use in the treatment of diseases and disorders.
Claims21
A chimeric antigen receptor (CAR) comprising:
- a) a signal peptide;
- b) a light chain variable region comprising the amino acid sequence:
- DIVMTQSHKFMSTSIGARVSITCKASQDVRTAVAWYQQKPGQ
- SPKWYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVY
- YCQQHYGTPPWTFGGGTKLEIK
- c) a linker peptide;
- d) a heavy chain variable region comprising the amino acid sequence:
- EVQLVESGGGLVKPGGSLKLSCEASRFTFSSYAMSWVRQTPE
- KRLEWVAAISGGGRYTYYPDSMKGRFTISRDNAKNFLYLQMS
- SLRSEDTAMYYCARHYDGYLDYWGQGTTLTVSS;
- e) a CD8α hinge polypeptide;
- f) a CD8α transmembrane domain;
- g) a 4-1BB costimulatory domain;
- and
- h) a CD3ζ signaling domain.
12 more elements
A chimeric antigen receptor (CAR) comprising:
- a) a signal peptide;
- b) a light chain variable region comprising the amino acid sequence:
- DIVMTQSHKFMSTSIGARVSITCKASQDVRTAVAWYQQKPGQSP
- KWYSASYRYTGVPDRFTGSGSGTDFTFTISSVQAEDLAVYYCQQ
- HYGTPPWTFGGGTKLEIK
- c) a linker peptide;
- d) a heavy chain variable region comprising the amino acid sequence:
- EVQLVESGGGLVKPGGSLKLSCEASRFTFSSYAMSWVRQTPEKR
- LEWVAAISGGGRYTYYPDSMKGRFTISRDNAKNFLYLQMSSLRS
- EDTAMYYCARHYDGYLDYWGQGTTLTVSS;
- e) a CD8α hinge polypeptide;
- f) a CD8α transmembrane domain;
- g) a CD28 costimulatory domain;
- and
- h) a CD3ζ signaling domain.
12 more elements
-30. (canceled)
Dependencies are inferred from the claim text.