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US 2020/0369726 A1Published application
Peptides and other agents for treating pain and increasing pain sensitivity
AssigneeThe Research Foundation for The State University of New York
InventorsArindam BHATTACHARJEE, Kerri PRYCE
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Abstract
Described herein are peptides that can be used to treat pain or increase pain sensitivity in subject in need of treatment. Additionally, peptides of the present disclosure can be administered with an analgesic agent and/or anesthetic agent. Peptides of the present disclosure are suitable for use when a subject in need of treatment has an injury, a chronic disease, a chronic inflammation, Morton's neuroma, operative/post-operative pain, or a combination thereof.
Claims28
A peptide comprising the following sequence:
- (SEQ ID NO:
- 75)
- X1X2X3X4X5X6PX7YX8X9VX10X11X12,
- wherein X1 is chosen from S, P, and A;
- X2 is chosen from T, S, and A;
- X3 is chosen from A and T;
- X4 is chosen from A, T, I, and S;
- X5 is chosen from C, S, and F;
- X6 is chosen from P and L;
- X7 is any amino acid residue;
- X8 is chosen from E, D and Y;
- X9 is chosen from S and R;
- X10 is chosen from T, A, E, and D, and T is optionally phosphorylated;
- X11 is chosen from K and R;
- and
- X12 is chosen from P, A, and G,
- wherein X1, X2, X3, X4, X10, X11, or a combination thereof is acylated.
14 more elements
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Dependencies are inferred from the claim text.