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US 2020/0369712 A1Published application
Methods for preparing bile acids
AssigneeMedytox Inc.
InventorsDejun LIU, Yingzhe QIAN, Junho LEE, Yoonseok SONG
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AssigneeMedytox Inc.
InventorsDejun LIU, Yingzhe QIAN, Junho LEE, Yoonseok SONG
Estimating the term…
The present disclosure provides methods of preparing cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, and novel and useful synthetic intermediates, for example, as described for methods 1, 1A, 1B, 2, 3, 3A, and 4. The method can start with a plant derived steroid as a starting material, such as dehydroepiandrosterone (DHEA) or Acetyl-dehydroepiandrosterone (Ac-DHEA). Also provided are pharmaceutical or cosmetic compositions and uses thereof, which comprise one or more of cholic acid, deoxycholic acid, or chenodeoxycholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof, which is of high purity, for example, free of animal derived impurities.
-37. (canceled)
A method of preparing cholic acid, an ester thereof, or a pharmaceutically or cosmetically acceptable salt thereof,
A method of preparing a compound of Formula III-8a
-64. (canceled)
A compound of Formula V-1, Formula V-2, Formula V-3, or Formula V-4, or a geometric isomer thereof, or a salt thereof:
A compound having a structure of
A compound of Formula V-5, Formula V-6, or Formula V-7, or a compound of Formula V-8 or a geometric isomer or a salt thereof:
A high purity cholic acid composition comprising cholic acid, or a salt thereof, and one or more compounds selected from Compounds 32-35, or a salt thereof:
-73. (canceled)
-76. (canceled)
Dependencies are inferred from the claim text.