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US 2020/0369704 A1Published application
Immunogenic trehalose compounds and uses thereof
AssigneeThe University of Montana
InventorsDavid Burkhart, Jay Evans, Craig Johnson, Kendal T. Ryter, Alyson Smith, Walid Abdelwahab Marzouky Abdelwahab
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Abstract
Disclosed herein are immunogenic trehalose compounds and methods of use thereof, for example as vaccine adjuvants.
Claims23
A compound of formula (I),
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from azido, alkynyl, and a five-membered heteroaryl ring having 1, 2, or 3 heteroatoms independently selected from N, O, and S, wherein the heteroaryl ring is optionally substituted with one substituent R3;
- R2 is selected from azido, alkynyl, and a five-membered heteroaryl ring having 1, 2, or 3 heteroatoms independently selected from N, O, and S, wherein the heteroaryl ring is optionally substituted with one substituent R4;
- wherein at least one of R1 and R2 is heteroaryl;
- R3 and R4 are each independently selected from Ar, alkyl, heteroalkyl, alkenyl, and heteroalkenyl;
- Ar is selected from an aryl or heteroaryl unsubstituted or substituted with one or more substituents independently selected from hydroxy, alkoxy, alkyl, and heteroalkyl;
- and
- each alkyl or heteroalkyl is independently unsubstituted or substituted with one or more substituents independently selected from hydroxy, amino, oxo, thioxo, halo, and haloalkyl.
5 more elements
Dependencies are inferred from the claim text.