Anti-pain compound and preparation method thereof

A method for preparing a compound represented by Formula (I), the method comprising:

• (1) dissolving a halogenated benzene reagent (A), a metal catalyst, a ligand, and an alkali as raw materials in a solvent, then adding 1-Boc-piperazine (B), and reacting under argon atmosphere at a reaction temperature of 40° C. to 140° C., to obtain an intermediate compound (C);
• (2) adding an hydrochloric acid-organic solvent to the intermediate compound (C) and stirring at room temperature to obtain a deprotected intermediate (D);
• and
• (3) dissolving the deprotected intermediate (D) into a solvent, and reacting with 1,4-dibromobutane in the presence of NaHCO3 to obtain the compound of Formula (I),
• wherein, in step (1) and step (3), the solvent is alcohol, ketone, nitrile, chlorinated hydrocarbon solvent, benzene-type solvent, DMSO or DMF;
• the metal catalyst is palladium chloride, copper acetate, cuprous iodide or ferric trichloride;
• the ligand is α-amino acid, o-hydroxybenzamide or binaphthol;
• in step (2), the organic solvent is an alcohol or ester solvent.