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US 2020/0369664 A1Published application
Sulfone compounds and derivatives for the treatment and prophylaxis of virus infection
AssigneeHoffmann-La Roche Inc.
InventorsChungen LIANG, Jianping WANG, Hongying YUN, Kun MIAO
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Abstract
The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their prodrugs or pharmaceutically acceptable salts, enantiomers or diastereomers thereof, and compositions including the compounds and methods of using the compounds.
Claims19
A compound of formula (I),
- wherein:
- R1 is C1-6 alkyl;
- R2 is phenyl C1-6 alkyl, said phenyl being unsubstituted or substituted by one, two or three substituents independently selected from halogen, C1-6 alkoxy and C1-6 alkyl;
- and
- R3 is —NR4R5, wherein:
- R4 and R5 are independently selected from C1-6 alkyl or C1-6 alkoxy 1-6 alkyl;
- or
- R4 and R5 together with the nitrogen they are attached to form a heterocyclyl;
- or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.
6 more elements
A compound selected from:
- 6-amino-9-benzyl-N-ethyl-N-methyl-8-oxo-2-propylsulfonyl-purine-7-carboxamide;
- 6-amino-9-benzyl-N-methyl-8-oxo-N-propyl-2-propyl sulfonyl-purine-7-carboxamide;
- 6-amino-9-benzyl-N-ethyl-2-ethylsulfonyl-N-methyl-8-oxo-purine-7-carboxamide;
- 6-amino-9-benzyl-2-ethyl sulfonyl-N-methyl-8-oxo-N-propyl-purine-7-carboxamide;
- 6-amino-9-benzyl-2-ethylsulfonyl-7-(pyrrolidine-l-carbonyl)purin-8-one;
- 6-amino-9-[(4-chlorophenyl)methyl]-N-methyl-8-oxo-N-propyl-2-propylsulfonyl-purine-7-carboxamide;
- 6-amino-9-[(4-chlorophenyl)methyl]-N-ethyl-N-methyl-8-oxo-2-propylsulfonyl-purine-7-carboxamide;
- 6-amino-9-[(4-chlorophenyl)methyl]-2-ethylsulfonyl-N-methyl-8-oxo-N-propyl-purine-7-carboxamide;
- 6-amino-9-[(4-chlorophenyl)methyl]-N-ethyl-2-ethylsulfonyl-N-methyl-8-oxo-purine-7-carboxamide;
- 6-amino-9-[(4-chlorophenyl)methyl]-2-ethylsulfonyl-N,N-dimethyl-8-oxo-purine-7-carboxamide;
- 6-amino-9-[(4-chlorophenyl)methyl]-2-ethylsulfonyl-N-(2-methoxyethyl)-N-methyl-8-oxo-purine-7-carboxamide;
- 6-amino-N-methyl-8-oxo-N-propyl-2-propylsulfonyl-9-(p-tolylmethyl)purine-7-carboxamide;
- 6-amino-N-ethyl-N-methyl-8-oxo-2-propylsulfonyl-9-(p-tolylmethyl)purine-7-carboxamide;
- 6-amino-2-ethylsulfonyl-N-methyl-8-oxo-N-propyl-9-(p-tolylmethyl)purine-7-carboxamide;
- 6-amino-N,N-diethyl-2-ethylsulfonyl-8-oxo-9-(p-tolylmethyl)purine-7-carboxamide;
- 6-amino-N-ethyl-2-ethylsulfonyl-N-methyl-8-oxo-9-(p-tolylmethyl)purine-7-carboxamide;
- 6-amino-2-ethylsulfonyl-9-(p-tolylmethyl)-7-(pyrrolidine-l-carbonyl)purin-8-one;
- 6-amino-2-ethylsulfonyl-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-N-propyl-purine-7-carboxamide;
- 6-amino-N-ethyl-2-ethylsulfonyl-9-[(4-fluorophenyl)methyl]-N-methyl-8-oxo-purine-7-carboxamide;
- 6-amino-9-[(4-methoxyphenyl)methyl]-N-methyl-8-oxo-N-propyl-2-propylsulfonyl-purine-7-carboxamide;
- 6-amino-N-ethyl-9-[(4-methoxyphenyl)methyl]-N-methyl-8-oxo-2-propylsulfonyl-purine-7-carboxamide;
- 6-amino-9-[(4-bromophenyl)methyl]-2-ethylsulfonyl-N-methyl-N-propyl-8-oxo-purine-7-carboxamide;
- and
- 6-amino-9-[(4-bromophenyl)methyl]-N-ethyl-2-ethylsulfonyl-N-methyl-8-oxo-purine-7-carboxamide;
- or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.
22 more elements
The method of claim 19, wherein the compound is present in a pharmaceutical composition that comprises a therapeutically inert carrier.
Dependencies are inferred from the claim text.