Selective ligands for tau aggregates
AssigneeKarin & Sten Mortstedt Cbd Solutions AB
InventorsPeter NILSSON, Hamid SHIRANI
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Abstract
The invention provides compounds of formula (I) and compositions comprising compounds of formula (I). The invention further provides uses of the compounds of formula (I) and compositions comprising compounds of formula (I), including the use of such compounds for the detection of tau deposits, and the use of such compounds and compositions as diagnostic agents in the diagnosis or monitoring of the progression of a disease or disorder such as Alzheimer's disease or corticobasal degeneration, or for the prevention or treatment of a disease or disorder such as Alzheimer's disease or corticobasal degeneration.
Claims22
A compound of formula (I) or a pharmaceutically acceptable salt, ester, amide or carbamate thereof, or a salt of such an ester, amide or carbamate,
- wherein
- W is S, O or Se;
- X is N or N+—R2;
- Y is S or O;
- Z is CH or N;
- or Y is Se and Z is CH;
- B is a 5 to 10 membered aromatic heterocycle having 1 to 3 heteroatoms selected from the group consisting of S, N, O and Se;
- Each R1 is independently selected from the group consisting of —O—C1-6alkyl, —O-monohaloC1-6alkyl, —O-dihaloC1-6alkyl, —O-trihaloC1-6alkyl, C1-6alkyl, monohaloC1-6alkyl, dihaloC1-6alkyl, trihaloC1-6alkyl, OH, F, Br, I, and CN;
- R2 is selected from the group consisting of C1-6alkyl, monohaloC1-6alkyl, dihaloC1-6alkyl, trihaloC1-6alkyl, and C(O)C1-6alkyl;
- Each R3 is independently selected from the group consisting of —O—C1-6alkyl, —O-monohaloC1-6alkyl, -O-dihaloC1-6alkyl, —O-trihaloC1-6alkyl, —(CH2)p—O—C1-6alkyl, —(CH2)q—C(O)—C1-6alkyl, —(CH2)r—C(O)—O—C1-6alkyl, —(CH2)s—N(R5)2, OH, F, Cl, Br, I, —CN, —C1-6alkyl, monohaloC1-6alkyl, dihaloC1-6alkyl, and trihaloC1-6alkyl;
- R4A and R4B are independently selected from the group consisting of H, OH, F, Cl, Br, I, C1-6alkyl, monohaloC1-6alkyl, dihaloC1-6alkyl, trihaloC1-6alkyl, O—C1-6alkyl, —O-monohaloC1-6alkyl, —O-dihaloC1-6alkyl, and —O-trihaloC1-6alkyl;
- Each R5 is independently selected from the group consisting of H and C1-6alkyl;
- m is 0, 1, 2 or 3;
- n is 0, 1, 2 or 3;
- p is 1, 2 or 3, q is 0, 1, or 2;
- r is 0, 1, or 2;
- and s is 0, 1, 2, or 3.
Dependencies are inferred from the claim text.