5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1h-tetrazole for the topical treatment of bacterial infections
AssigneeDenovamed Inc.
InventorsFan Wu, Christopher R. McMaster, Donald F. Weaver
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Abstract
A compound 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole, methods for the manufacture of said compound, topical compositions comprising said compound and methods of use thereof in the topical treatment of infections caused by pathogenic bacteria as a wound site.
Claims16
5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole or a pharmaceutically acceptable salt thereof, and a dermatologically acceptable carrier.
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A method of eradicating pathogenic bacteria within a diabetic ulcer in an individual in need of such treatment, the method comprising applying a composition comprising an effective amount of 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole upon the ulcer.
A method of treatment of diabetic foot infection in an individual in need thereof, the individual having a site of infection, the method comprising applying a composition comprising an effective amount of 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole to the site.
A method of treatment of cellulitis in an individual in need thereof, the individual having a site of infection, the method comprising applying a composition comprising an effective amount of 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole to on the site.
A method of manufacture of 5-(2,5-bis(4-chloro-2-isopropylphenyl)thiophen-3-yl)-1H-tetrazole, or a pharmaceutically acceptable salt thereof, the method comprising reacting a mixture of N-protected 5-bromotetrazoles with thiophen-3-ylboronic acid under palladium cross-coupling conditions.
Dependencies are inferred from the claim text.