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AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsMelvin L. DePamphilis, Gaurav Sharma, Juan Jose Marugan, Marc Ferrer, Ajit Roy
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Disclosed is method for treating cancer in a mammal, comprising administering to a mammal in need thereof a compound of the formula: wherein R1, R2, and R3 are as defined herein, wherein the cancer is an autophagy-dependent cancer, in an amount sufficient to induce autophagy in the cell and cause the death of cancer cells. Also disclosed is a method for selectively killing cancer cells in a patient afflicted with cancer, comprising administering to the mammal, wherein the cancer cells are autophagy-dependent cancer cells, in an amount sufficient to induce autophagy in the cells and cause the death of the cancer cells.
A method of (a) treating cancer in a mammal, wherein the cancer is an autophagy-dependent cancer or (b) selectively killing cancer cells in a mammal afflicted with cancer, wherein the cancer cells are autophagy-dependent cancer cells, comprising administering to the mammal an effective amount of a compound selected from:
Dependencies are inferred from the claim text.