Prodrugs of Nrf2 Activating Compounds and Uses Thereof

A method of treating a disease of disorder in a subject in need thereof, the method comprising:

• administering to the subject a pharmaceutically effective amount of a compound of formula (I):
• wherein:
• R2 is selected from the group consisting of sulfonyl, carboxyl, carboxyl ester, and aminoacyl;
• R3 is selected from the group consisting of an active agent, an antioxidant, an amino acid, an amino acid derivative, a peptide, and a peptide derivative;
• R4 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
• X1 and X2 are each independently selected from N and CH, wherein at least one of X1 and X2 is N;
• and
• n is an integer from 1 to 6,
• or a salt or a stereoisomer thereof,
• wherein the administering is sufficient to treat the disease or disorder, and wherein the disease or disorder is selected from the group consisting of cardiac insufficiency, asthma, arthritis, an inflammatory bowel disease, and a chronic obstructive pulmonary disease.