Nir-conjugated tumor-specific antibodies and uses thereof
AssigneesCity of Hope, The Regents of the University of California
InventorsPaul YAZAKI, Jack SHIVELY, Michael BOUVET, Jonathan DELONG, Yuman FONG
Life of this patent
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Abstract
Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.
Claims23
An antibody-fluorophore conjugate comprising a tumor-specific antibody conjugated to a near-infrared (NIR) fluorophore, wherein the antibody is a humanized antibody.
A method of detecting or localizing a solid tumor in a subject, comprising:
- a) administering to the subject an antibody-fluorophore conjugate comprising a tumor specific antibody conjugated to a near-infrared (NIR) fluorophore;
- and
- b) scanning the subject with a scanning device at one or more time points after administration thereby to detect or localize the tumor.
A method of tumor imaging to direct surgical resection of a solid tumor in a subject, comprising:
- a) administering to the subject an antibody-fluorophore conjugate comprising a tumor-specific antibody conjugated to a near-infrared (NIR) fluorophore;
- and
- b) scanning the subject with a scanning device at one or more time points after administration thereby to guide resection of the tumor.
Dependencies are inferred from the claim text.