Compounds and compositions for targeting brain injuries and methods of use thereof
AssigneeSanford Burnham Prebys Medical Discovery Institute
InventorsErkki Ruoslahti, Aman Mann, Pablo Scodeller, Sazid Hussain
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Abstract
Compositions are disclosed which include a CAQK peptide linked or conjugated to a cargo composition, where the peptide selectively homes the composition to a site of nervous system injury in a subject.
Claims15
A composition comprising a peptide linked or conjugated to a cargo composition, wherein the peptide comprises the amino acid sequence CAQK (SEQ ID NO:4) and selectively homes the composition to a site of nervous system injury in a subject.
A method of selectively targeting CSPG-rich extracellular matrix complexes, the method comprising administering a composition to a subject, wherein the composition comprises a peptide comprising the amino acid sequence CAQK (SEQ ID NO:4) and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.