Vault Complexes for Cytokine Delivery
AssigneesThe Regents of the University of California, The United States Govemment as represented by the Department of Veterans Affairs
InventorsLeonard H. Rome, Valerie Ann Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar
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Abstract
The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.
Claims52
A composition comprising a vault complex comprising a chemokine fusion protein comprising a chemokine (C—C motif) ligand 21 (CCL-21) consisting of the amino acid sequence of SEQ ID NO:2 (human) and a major vault protein interaction domain (mINT) consisting of the amino acid sequence of SEQ ID NO:8 (human).
A composition comprising a vault complex comprising a fusion protein comprising a cytokine and a vault targeting domain.
An isolated nucleic acid encoding a chemokine fusion protein comprising a cytokine encoding sequence and a mINT encoding sequence.
Dependencies are inferred from the claim text.